目的黑色素瘤缺乏因子2(absent in melanoma 2,AIM2)是近年来新发现的一种炎症小体,其与肿瘤发生发展的相关性研究备受关注。本研究分析联合检测结直肠癌组织中AIM2表达与术前血清癌胚抗原(carcinoembryonic antigen,CEA)水平与结直肠癌患者预后的关系并探讨两者联合检测的临床价值。方法应用免疫组化检测收集于2009-10-13-2014-04-09苏州大学附属第二医院普外科142例结直肠癌患者的肿瘤组织标本及其中41例癌旁正常组织标本中AIM2的表达水平,同时回顾性搜集该142例患者术前肿瘤血清CEA水平及临床病理参数,分析结直肠癌组织中AIM2表达水平和术前血清CEA水平与临床病理特征的关系。Spearman等级相关性分析结直肠癌组织中AIM2表达水平与术前血清CEA水平的相关性。Kaplan-Meier生存曲线分析不同AIM2、CEA表达水平组别总生存率的差异;Cox比例风险回归模型进行单因素和多因素生存分析AIM2表达水平和术前血清CEA水平与患者预后的关系。结果AIM2在结直肠癌组织中的表达率为32.4%(46/142),明显低于癌旁正常组织的80.5%(33/41),χ2=29.994,P<0.001;其表达水平与肿瘤的浸润深度(χ2=5.383,P=0.020)、TNM分期(χ2=8.648,P=0.013)和淋巴结转移(χ2=4.947,P=0.026)有关联。患者术前血清CEA的阳性率为41.5%(59/142),其表达与肿瘤大小(χ2=11.338,P=0.001)、肿瘤浸润深度(χ2=5.197,P=0.023)和TNM分期(χ2=6.607,P=0.037)有关联。结直肠癌组织中AIM2表达水平与术前血清CEA水平呈负相关,r=-0.217,P=0.009。Kaplan-Meier生存分析显示,AIM2高表达患者总生存率(78.3%)明显高于低表达组(50.0%),中位生存期分别为61和48个月,χ2=10.686,P=0.001;而术前CEA阳性患者总生存率(45.8%)明显低于阴性组(79.7%),中位生存期分别为45和62个月,χ2=8.549,P=0.003。与AIM2高表达+CEA阳性组、AIM2低表达+CEA阳性组和AIM2低表达+CEA阴性组相比,AIM2高表达+CEA阴性组总生存率最高(88.0%),中�
目的:分析Sternberg管未闭的病因、临床特点,并指导临床诊断及治疗。方法:收集近1年本医疗组治疗Sternberg管未闭患者的临床资料,并检索国内外数据库收集相关病例进行回顾性分析。结果:2例病例均有明确Sternberg管未闭伴脑膜脑膨出的影像学特征,经过手术治疗后未见明显脑脊液漏表现。文献检索共得相关研究22篇,其中病例为51例,以自发性脑脊液鼻漏为主要症状,均有明确蝶窦骨质缺陷,手术治疗预后良好。结论:Sternberg管人群中发病率低,主要引起不明原因的脑脊液鼻漏。其临床诊断困难,但手术可治愈,预后好,复发率低。Objective: To analyze the etiology and clinical characteristics of patent Sternberg’s Canal, and to guide clinical diagnosis and treatment. Method: We collect clinical data of patients with patent Sternberg’s Canal treated in our medical group in recent years and retrieve relevant cases from Chinese and foreign databases for retrospective analysis. Result: Both two cases had explicit imaging features of patent Sternberg’s Canal along with meningoencephalocele. No obvious cerebrospinal fluid leakage was observed after surgical treatment. A total of 22 relevant studies were obtained through literature search, including 51 cases, with spontaneous cerebrospinal fluid rhinorrhea as the main symptom. All of them had clear sphenoid sinus bone defects and had good prognosis after taking surgical treatment. Conclusion: In epidemiology, the incidence rate in Sternberg’s Canal is low, which mainly causes cerebrospinal fluid rhinorrhea of unknown causes. It is difficult to make clinical diagnosis, but it can be cured by surgery, with good prognosis and low recurrence rate.
