糖尿病是缺血性脑卒中的重要危险因素之一,钠葡萄糖协同转运蛋白抑制剂作为一种新型的降糖药可通过抑制肾脏血管对葡萄糖吸收而起到控制血糖作用,同时有抑制动脉粥样硬化、降脂及减轻体重等功能。本文通过从钠–葡萄糖协同转运蛋白2抑制剂作用机制出发,结合既往基础及临床研究报告。对钠–葡萄糖协同转运蛋白2抑制剂对缺血性脑血管病的影响及作用机制作一简要综述。Diabetes mellitus is one of the most important risk factors for ischemic stroke. Sodium-glucose cotransporter protein inhibitors, as a new type of hypoglycemic drugs, can control blood glucose by inhibiting glucose uptake by renal blood vessels, and at the same time inhibit atherosclerosis, lower lipids and reduce body weight. In this paper, the mechanism of sodium-glucose cotransporter protein 2 inhibitor is analyzed from the perspective of its mechanism of action, combined with the reports of previous basic and clinical studies. The effects of sodium-glucose cotransporter 2 inhibitors on ischemic cerebrovascular disease and its mechanism of action are briefly summarized.
目的比较研究紫外辐射强度、日照时间与腰椎骨密度(bone mineral density,BMD)的关系.方法检索国内公开发表的使用同一公司生产的双能X线骨密度仪(DXA)测量腰椎(L1-L4和L2-L4)BMD文章共12篇,与昆明地区8 774例腰椎BMD比较.将该13个地区的骨密度值转化成标准化骨密度值(s BMD).通过中国科学院生态系统研究网络找到相应地区的年平均紫外辐射强度及年平均日照时间.研究不同年龄段、不同性别的人群紫外辐射强度、日照时间与腰椎BMD的关系.结果该13个地区各年龄段男性和女性紫外辐射强度与腰椎BMD无相关性;该13个地区各年龄段男性和女性日照时间与腰椎BMD无相关性.结论该13个地区紫外辐射强度、日照时间对腰椎BMD的影响无差异.
