椎间盘退变是一种复杂的与年龄相关的生物学改变,受到多种因素影响。随着人口老龄化和生活方式的改变,其发病率不断上升,给社会带来沉重负担。外泌体作为细胞间交流的重要媒介,在椎间盘退变过程中具有关键作用。本文详细综述了外泌体的基本特性,深入探讨了其在椎间盘退变中的作用机制,包括对髓核细胞功能、炎症反应、细胞外基质代谢和细胞间通讯的影响,并阐述了基于外泌体的治疗策略以及面临的挑战与展望,旨在为椎间盘退变的研究和治疗提供新的思路。Intervertebral disc degeneration is a complex age-related biological change affected by multiple factors. With the aging of the population and the change of lifestyle, its incidence is increasing, which brings a heavy burden to society. As an important medium of intercellular communication, exosomes play a key role in the process of intervertebral disc degeneration. In this paper, the basic properties of exosomes are reviewed in detail, and the mechanism of action of exosomes in intervertebral disc degeneration is discussed in detail, including their effects on nucleus pulposus cell function, inflammatory response, extracellular matrix metabolism and intercellular communication. In addition, exosome-based therapeutic strategies, challenges and prospects are described, with the aim of providing new ideas for the research and treatment of intervertebral disc degeneration.
ChatGPT作为生成式人工智能的典型代表,其影响力如汹涌浪潮般席卷各个行业,教育领域也未能幸免,遭受着强烈冲击。在这个时代背景下,中医骨伤科学教育面临着前所未有的严峻挑战。例如,ChatGPT生成的信息可能不准确,影响学生知识掌握;其便捷性可能削弱学生独立思考能力;还可能引发学术作弊等问题。为应对这些挑战,本文提出了一系列针对性策略:强化人工智能素养教育,让学生了解ChatGPT原理,识别信息准确性;优化教学方法和内容,设计批判性思维任务等;建立完善评价体系,多元化评价并加强诚信教育与监管;促进人机协同教育,挖掘育人价值等。以此维护中医骨伤科学教育的独特性与有效性,为培养符合时代需求的中医骨伤科人才给予理论与实践的有力支撑。As a typical representative of generative artificial intelligence, the influence of ChatGPT swept through various industries like a surging wave, and the education field has not been spared, suffered a strong impact. Under the background of this era, the bone and injury science education of traditional Chinese medicine is facing unprecedented severe challenges. For example, the information generated by ChatGPT may be inaccurate, affecting students’ knowledge grasp;Its convenience may weaken students’ ability to think independently;It can also lead to problems such as academic cheating. In order to deal with these challenges, this paper puts forward a series of targeted strategies: enhancing artificial intelligence literacy education to help students comprehend the principles of ChatGPT and assess the accuracy of information;optimizing teaching methods and content by designing critical thinking tasks, among other strategies;establishing and refining the evaluation system to diversify assessment approaches while strengthening integrity education and supervision;promoting human-machine collaborative education and exploring the value of such educational initi
胃癌前病变(Precancerous Lesions of Gastric Cancer, PLGC)是胃癌发生前的关键阶段,涵盖慢性萎缩性胃炎(Chronic Atrophic Gastritis, CAG)伴肠上皮化生和异型增生等情况。本文深入探讨中医药治疗胃癌前病变的优势,从病因病机、治疗方案等多方面展开详细论述,并参考《黄帝内经》及《素问》等中医经典,旨在为临床实践提供有力指导。Precancerous Lesions of Gastric Cancer (PLGC) are a crucial stage in the development of gastric cancer, encompassing conditions such as chronic atrophic gastritis (CAG) with intestinal metaplasia and dysplasia. This article delves into the advantages of traditional Chinese medicine (TCM) in treating PLGC, providing a detailed discussion from the perspective of etiology and pathogenesis, as well as treatment plans. It also references classic Chinese medicine texts such as the Yellow Emperor’s Inner Canon and the Suwen to provide guidance for clinical practice.
