随着冠脉介入治疗技术(Percutaneous Coronary Intervention, PCI)的发展和进步,以及术后新型抗血小板聚集药物和抗凝药物的广泛使用,冠状动脉性心脏病(简称冠心病,coronary heart disease, CHD)患者的临床预后得到显著改善,CHD相关的并发症也显著降低。然而,PCI术后非罪犯血管(non-culprit coronary lesions, NCCLs)病变进展的问题,仍是影响患者长期生存率和预后的重要挑战。因此,深入探讨和解决NCCLs病变进展的机制、病理生理过程、影响因素,并在此基础上制定有效的治疗和预防策略,对进一步改善患者预后,进一步降低死亡率具有一定的临床意义和研究价值。With the advancement and development of percutaneous coronary intervention (PCI) techniques, along with the widespread use of novel antiplatelet and anticoagulant agents postoperatively, the clinical prognosis of patients with coronary heart disease (CHD) has significantly improved, and the incidence of CHD-related complications has markedly decreased. However, the progression of non-culprit coronary lesions (NCCLs) after PCI remains a critical challenge affecting long-term survival and prognosis. Therefore, in-depth exploration of the mechanisms, pathophysiological processes, and influencing factors of NCCLs progression, as well as the development of effective therapeutic and preventive strategies based on these findings, holds significant clinical and research value for further improving patient outcomes and reducing mortality rates.
