病理性瘢痕是指在伤口愈合过程中,各种原因导致的胶原的合成代谢与降解代谢之间的平衡破坏而形成的胶原纤维增生性疾病。现代医学治疗瘢痕主要采用手术和药物,手术可能会产生新的瘢痕,药物治疗效果亦欠佳。针灸疗法作为中医外治法的一种,对瘢痕有通经散结、活血祛瘀的功效,在瘢痕治疗中取得良好疗效。本文就各种针灸疗法在瘢痕的临床应用中的进展进行综述。Pathological scarring refers to a proliferative disorder of collagen fibers formed due to the disruption of the balance between anabolic and catabolic collagen metabolism during wound healing, caused by various factors. Modern medical treatments for scars primarily involve surgery and medications. However, surgery may lead to the formation of new scars, and pharmacological treatments often yield suboptimal results. Acupuncture therapy, as a form of external treatment in traditional Chinese medicine, has the effects of unblocking meridians and dispersing nodules, as well as promoting blood circulation to remove blood stasis, and has achieved good efficacy in scar treatment. This article reviews the progress of various acupuncture and moxibustion therapies in the clinical application for scar treatment.
目的：探讨乙醇是否通过参与调节培养的人巨噬细胞细胞内白介素1α（IL-1α）的分泌过程，从而发挥对冠状动脉心脏疾病的保护作用。方法：培养人的人单核巨噬细胞系（THP-1）至2-3代后，加入佛波酯（PMA）孵育72 h 诱导THP-1细胞分化为巨噬细胞。用ELIAS 方法检测脂多糖（LPS）、胆固醇（CHOL）及乙醇（ethanal）对巨噬细胞分泌IL-1α的影响。结合ELISA结果，用Western blot 方法检测乙醇对Caspase-1、NLRP3蛋白表达情况。结果：与空白对照组相比，LPS组及LPS ＋ CHOL组IL-1α的浓度升高。与LPS ＋CHOL 组比较，LPS ＋ CHOL ＋ etha 组 IL-1α的浓度显著下降（P ＜0．01）。 Western blot 结果显示乙醇抑制Caspase-1、NLRP3蛋白激活。结论：乙醇抑制巨噬细胞中NLRP3炎性小体激活可能是适度饮酒对冠状动脉心脏疾病的潜在保护作用的生物学途径。
