目的:讨论发生在四肢长骨的淋巴瘤的影像特征。方法:回顾性分析22例经淋巴结活检、骨髓穿刺或手术病理证实为四肢长骨淋巴瘤患者的影像,总结其影像学特征。结果:CT检查12例,均有骨质破坏,其中83.3% (10/12)为溶骨型,8.3% (1/12)为混合型,8.3% (1/12)为硬化型,66.7% (8/12)呈偏心性;66.7% (8/12)呈现“骨小破坏、软组织大肿块”;58.3% (7/12)有骨膜反应;25% (3/12)伴病理骨折;75% (9/12)存在“浮冰征”;25% (3/12)见“骨皮质开窗征”。MRI检查20例,40% (8/20)T2WI表现出“马赛克征”;45% (9/20)肿块超出骨破坏范围;40% (8/20)见“骨皮质开窗征”;MRI增强扫描5例,80% (4/5)见“镶边征”。结论:本研究表明:发生在四肢长骨的淋巴瘤具有特定征象,当病变表现为溶骨性、偏心性骨质破坏,出现“骨小破坏、软组织大肿块”,以及“浮冰征”、“骨皮质开窗征”、“镶边征”、骨膜反应及T2WI“马赛克征”时,应高度怀疑长骨淋巴瘤的诊断。Purpose: To discuss the imaging features of lymphoma occurring in the long bones. Methods: Reviewing 22 cases with lymphoma of the long bones confirmed by lymph node biopsy, bone marrow aspiration, or surgical pathology. Analyzing and summarizing their radiological features. Results: Of the 12 patients who underwent CT scans, all had bone destruction;83.3% (10/12) showed osteolytic lesions, 8.3% (1/12) presented mixed lesions, and another 8.3% (1/12) displayed sclerotic lesions;66.7% (8/12) displayed eccentric involvement;66.7% (8/12) manifests as a large soft tissue mass with small bone destruction;58.3% (7/12) exhibited periosteal reaction;25% (3/12) accompanied by pathological fracture;75% (9/12) demonstrated “ice-floating sign;” and 25% (3/12) demonstrated “windowing sign in cortical bone.” Of the 20 patients who underwent MRI, 40% (8/20) exhibited a “mosaic sign” on T2WI. 45% (9/20) of the masses extended beyond the extent of bone destruction. 40% (8/20) exhibited the