舌癌是最常见的口腔恶性肿瘤,随着口腔癌的发病率和舌癌的发病率的逐渐上升,导致其治疗进展正备受关注。目前治疗舌癌的主要方法包括手术、放疗和化疗以及靶向治疗。手术治疗为首选,传统的手术治疗方法主要是通过切除肿瘤组织和相应的淋巴结来达到治疗的目的,但是对于一些局部较为复杂的病例,单纯的手术治疗会导致颏神经等重要组织损伤,给患者的生存和生活质量带来很大的影响。故探讨基于微创手术技术的不裂开下唇下颌骨舌癌手术治疗方法,借助先进的医疗设备和技术手段,开展针对舌癌的精准切除和组织修复操作是必要的。本综述旨在阐明目前针对舌癌的不裂开下唇下颌骨手术研究进展,对未来的治疗和研究方向提供一定的临床思路。Tongue cancer is the most common malignant tumor in the oral cavity. With the increasing incidence of oral cancer and tongue cancer, their treatment advancements are receiving significant attention. Currently, the main methods for treating tongue cancer include surgery, radiation therapy, chemotherapy, and targeted therapy. Surgery is the preferred option, and traditional surgical methods mainly involve the removal of tumor tissue and corresponding lymph nodes to achieve the treatment goals. However, for some cases with complex local conditions, the use of conventional surgical treatment alone may result in damage to important tissues such as the lingual nerve, significantly impacting the patient’s survival and quality of life. Therefore, exploring minimally invasive surgical techniques for non-splitting mandibular tongue cancer surgery is necessary. Utilizing advanced medical equipment and technical means to perform precise resection and tissue repair for tongue cancer is crucial. This review aims to elucidate the current research progress in non-splitting mandibular tongue cancer surgery and provide clinical insights into future treatment and research directions
Atherosclerosis is a multiple-pathogeny disease that consists of many complicated processes,including oxidative stress,endothelium dysfunction,abnormal cell proliferation,apoptosis and extracellular matrix disorder.The pivotal proteases for these courses are NAD(P)H oxidase,eNOS,MAPKs and MMPs,respectively.As an upstream kinase,protein kinase C(PKC) may involve in the development of atherosclerosis through affecting these enzymes.
