目的:探讨放疗体积和不同放疗技术在胸部肿瘤中对淋巴细胞(Lymphocyte, Lym)及其亚群分布影响。方法:选取我科胸部恶性肿瘤放疗患者,通过测量靶区体积,计算放疗前后淋巴细胞的差值(ΔLym),进行相关性分析。对光子放疗组和质子放疗组治疗后Lym及其亚群分布进行比较。结果:ΔLym与靶区体积通过散点图观察无明显相关性。Pearson相关性分析r = 0.079,P = 0.672。在质子放疗组和光子放疗组放疗后对Lym总数存在明显差异(P = 0.04),质子放疗组Lym高于光子放疗组。CD3+ T细胞、CD19+ B细胞、抑制/细胞毒性T细胞CD8、辅助/诱导性T细胞CD4和CD16+ CD56 NK细胞数无差异。结论:放疗靶区体积与Lym变化无明显相关,质子放疗能减轻淋巴细胞的下降。Objective: Exploring the effects of radiotherapy volume and different radiotherapy techniques on the distribution of lymphocytes and their subsets in chest tumors. Method: Select patients with chest malignant tumors undergoing radiotherapy in our department, measure the volume of the target area, calculate the difference in lymphocytes before and after radiotherapy (ΔLym), and conduct correlation analysis. Compare the distribution of Lym and its subgroups after treatment between photon radiotherapy group and proton radiotherapy group. Result: There is no significant correlation observed between ΔLym and target volume through scatter plot analysis. Pearson correlation analysis r = 0.079, P = 0.672. There was a significant difference in the total number of Lym between the proton radiotherapy group and the photon radiotherapy group after radiotherapy (P = 0.04), with the proton radiotherapy group having a higher Lym count than the photon radiotherapy group. There was no difference in the number of CD3+ T cells, CD19+ B cells, CD8 inhibitory/cytotoxic T cells, CD4 helper/inducible T cells, and CD16+ CD56 NK cells. Conclusion: There is no significant correlation between the volume of the radiotherapy target area and
肺癌为常见肿瘤之一,晚期患者出现多发转移,但牙龈转移相对罕见,晚期以全身治疗为主,根据分子检测驱动基因选择靶向药物治疗。本文报道一例肺腺癌伴KIF5B-RET突变牙龈转移病例。Lung cancer is one of the common tumors, with multiple metastases in late-stage patients, but gingival metastases are relatively rare. In the late stage, systemic treatment is mainly used, and targeted drug therapy is selected based on molecular detection of driving genes. This article reports a case of gingival metastasis of lung adenocarcinoma with KIF5B RET mutation.
