To investigate the chemical components of the barks and twigs ofltoa orientalis. A new linear monoterpene glycoside named itoside O was isolated from the crude extract of Itoa orientalis together with 11 known compounds. The new compound was identified to be 3,7-dimethyl-1, 6-octadien-3, 10-dihydroxyl-10-O-α-L-arabinopyranosyl （1 -→6）-O-β-D-glucopyranoside by 1D and 2D NMR analysis, and all known compounds were isolated from this plant for the first time.
Efforts toward the total synthesis of indolactam V via CuI-mediated inter- and intra-molecular N-arylation of 4-iodotryptophan derivatives for the introduction of 4-valine moiety from natural L-valine are described. Meanwhile, the efficient synthesis of several pyrroloquinoline derivatives by taking advantage of the CuI-catalyzed intramolecular N-arylation reaction of 4-iodotryptophan is disclosed.
