[Objective] This research was to study the correlation regional climatic characteristics and changing geographic distribution of Populus euphratica Oliv. (Salicaceae), as well as the adaption of Populus euphratica Oliv. to the climatic environment. [Method] The climatic characteristics, water source, groundwater and soil type in the distribution regions of Populus euphratica Oliv. and the effect of long-term human activities were comprehensively analyzed based an overview of Populus euphratica Oliv. and its distribution. [Result] Specific regional climatic characteristics and long term human activities are the principle determinants for the growth of Populus euphratica Oliv. The change of leaf shape is a distinct feature of Populus euphratica Oliv. in adapting to the climatic environment. Populus euphratica Oliv. withstands various environmental stresses by means of in vivo synthesis, transport and conversion of secondary phenolic metabolites. Effective protection and rehabilitation measures, and ecological water transport have obvious effect on the restoration and reconstruction of damaged ecological environment of Populus euphratica oasis. [Conclusion] This study is of great significance for the restoration of ecological environment in the arid inland regions, north-west China.