高校作为人才培养的主阵地和重要场所,要站在维护国家安全、社会和谐稳定的高度,把安全工作纳入到国家安全的大格局中予以重视和落实。针对高校安全工作,阐述了高校构建大安全工作格局的内涵和意义,提出构建高校大安全工作体系的总体思路、主要内容、保障措施,介绍了西南交通大学大安全工作体系的构建与实践情况,总结了大安全工作体系运行中取得了师生员工的安全意识明显提升、构建了矩阵式的安全工作与管理模式、安全管理工作从被动实施转变为主动靠前营造良好氛围的效果。As the main battlefield and important place for talent cultivation, universities should stand at the height of maintaining national security and social harmony and stability, and attach importance to and implement security work in the overall national security framework. This article elaborates on the connotation and significance of building a comprehensive safety work pattern in universities, proposes the overall ideas, main contents, and guarantee measures for building a comprehensive safety work system in universities, introduces the construction and practice of the comprehensive safety work system in Southwest Jiaotong University, and summarizes the significant improvement in safety awareness among teachers, students, and employees in the operation of the comprehensive safety work system, the establishment of a matrix style safety work and management mode, and the transformation of safety management work from passive implementation to proactive creation of a good atmosphere.