目的:了解耐甲氧西林金黄色葡萄球菌临床感染现状和耐药变化趋势,为临床防治提供依据。方法:对2018年1月至2023年12月间,鄂尔多斯市中心医院门诊及住院患者所分离出的耐甲氧西林金黄色葡萄球菌标本来源、临床感染科室分布及耐药性变迁进行回顾性分析。采用全自动微生物鉴定仪对菌株进行鉴定和药敏试验,采用K-B纸片扩散法和E-test法进行补充试验。结果:2018~2023年共收集到219株MRSA,占总检出SAU的18.56%。科室中主要分离科室为重症医学科占22.83%,其次为神经外科占12.79%。标本以痰液标本为主,占59.82%,其次为分泌物占18.26%。MRSA与MSSA对利奈唑胺、达托霉素、万古霉素、替考拉宁四种药物尚未产生耐药性;但MRSA对复方新诺明的耐药性低于MSSA (p Objective: To investigate the current status of clinical infection and the trend of drug resistance of methicillin-resistant Staphylococcus aureus, and to provide a basis for clinical prevention and treatment. Methods: Conduct a retrospective analysis on the specimen sources, distribution in clinical infection departments, and alterations in the drug resistance of methicillin-resistant Staphylococcus aureus isolated from both outpatient and inpatient individuals in Ordos Central Hospital spanning from January 2018 to December 2023. The automatic microbial identification instrument was used to identify the strains and the antimicrobial susceptibility test, and the K-B disc diffusion method and E-test method were used to carry out supplementary tests. Results: A total of 219 MRSA strains were collected from 2018 to 2023, accounting for 18.56% of the total detected SAU. Among the departments, the main separate department was intensive care medicine, accounting for 22.83%, followed by neurosurgery (12.79%). Sputum samples were the main specimens, accounting for 59.82%, followed by secretion (18.26%). MRSA and MSSA have not yet developed resistance to daptomycin, linezolid, vancomycin, a
