肽基水凝胶作为生物活性材料在药学、纳米材料化学、组织工程等领域受到广泛关注。肽水凝胶的设计往往遵循自下而上的思路,即基于分子自组装的方法,以微观结构为基础扩展到宏观结构的形成。这种从微观角度出发的方法缺乏具体的模型阐述,初学者往往难以上手。因此,我们根据以β-折叠为基本自组装结构的肽基水凝胶的研究,总结了氨基酸对于肽自组装行为以及凝胶结构与应用的影响,期望可以帮助研究者在设计多肽序列时可以尽快地找到切入点,开发出具有特殊功能的肽基水凝胶材料。As bioactive materials, peptide-based hydrogels have attracted extensive attention in the fields of pharmacy, nanomaterial chemistry, tissue engineering, etc. The design of hydrogels often follows the bottom-up approach, that is the method based on molecular self-assembly, extending from microstructure to the formation of macrostructure. But this method from the micro-perspective lacks specific model elaboration, making it difficult to get started for beginners. Therefore, based on some studies on peptide-based hydrogels with β-sheet as the basic self-assembly structure, we summarized the influence of different amino acid sequences on peptide self-assembly behavior, and the structure and application of gel, hoping to help researchers find the entry point as soon as possible when designing peptide sequences, and design and develop peptide-based hydrogel materials with special functions.
