勃起功能障碍(ED)是男性常见的多因素疾病,其发病机制涉及血管内皮功能障碍,氧化应激,炎症反应和神经内分泌等疾病。丹参酮IIA (Tanshinone IIA)是从丹参中提取的主要活性成分,具有抗氧化、抗炎、改善微循环和保护血管内皮等药理作用。近年来,研究发现丹参酮IIA可以通过调节一氧化氮(NO)通路,抑制氧化应激和炎症反应来改善ED症状,但其具体机制仍有待进一步探讨。本文就丹参酮IIA的化学特性、药理作用;丹参酮IIA与勃起功能障碍的关联;丹参酮IIA治疗ED的研究进展进行如下综述,为ED的靶向治疗提供新思路。Erectile dysfunction (ED) is a common multifactorial disease in men, and its pathogenesis involves vascular endothelial dysfunction, oxidative stress, inflammatory response, and neuroendocrine disorders. Tanshinone IIA is the main active ingredient extracted from Salvia miltiorrhizae, which has pharmacological effects such as antioxidant, anti-inflammatory, improving microcirculation and protecting vascular endothelium. In recent years, research has shown that Tanshinone IIA can improve erectile dysfunction (ED) symptoms by modulating the nitric oxide (NO) pathway and inhibiting oxidative stress and inflammatory responses. However, the specific mechanisms still need to be further explored. This article reviews the chemical properties and pharmacological effects of Tanshinone IIA, the association between Tanshinone IIA and erectile dysfunction, and the research progress of Tanshinone IIA in treating ED, providing new ideas for targeted therapy of ED.
