Objective To seek safe, effective and popular penetration moxibustion therapy through exploring the optimum duration and temperature of penetration moxibustion by means of observing the relationship among the duration, temperature and effect of moxibustion on abdomen. Methods Thirty-two healthy persons were selected as subjects, and moxibustion was performed, centering on navels, on their abdomens. The temperature of moxibustion box was recorded once a minute since the beginning of moxibustion, and other items, including the temperature and time at which and when the subject felt heated, the temperature at which the subject felt reduced, temperature reduction time, temperature difference on the skin, time course of penetration moxibustion and subject＇s reaction, were also recorded. Results Among32 subjects, 2 dropped out from the study; flushing was shown on 30 subjects, sweating on 7, brindle on 5, and reaction on 7. The time course of penetration moxibustion was（28.37±2.37） min, the temperature at which the subject felt heated was（35.79±0.85） ℃, and the temperature at which the subject felt reduced was（44.23±1.62） ℃. Conclusion 1 During the course of penetration moxibustion, sense of warmth penetrate into abdominal cavity and waist from epidermis, and penetrate into head upwards and knee downwards;2 flushing, sweating and brindle are the important indices for the effect of penetration moxibustion; 3 penetration moxibustion can be lasted for 28–32 min, and the temperature should be controlled at 43–45 ℃, so as to not only reduce the impact of smoke on the indoor environment, but also make patients feel no pain.
目的系统评价针刺联合中药治疗非动脉炎性前部缺血性视神经病变(NAION)的临床疗效及证据等级。方法检索PubMed、Web of Science、Embase、中国知网、万方、维普、中国生物医学文献数据库中应用针刺联合中药治疗NAION的文献,检索时间为建库至2024年1月31日。由2名研究者按纳入与排除标准进行筛选,提取相关信息、数据和结局指标[总有效率、平均视野缺损(MD)、最佳矫正视力(BCVA)、平均视野敏感度(MS)、视网膜神经纤维层(RNFL)厚度],采用Cochrane协作网的风险偏倚评估工具评估纳入研究的方法学的质量,GRADE proGDT软件对结局指标进行证据分级推荐标准(GRADE)评价,RevMan 5.4软件进行数据分析。结果共纳入16项研究,1,027例患者(1,138只眼)。其中,试验组522例(586只眼)均以针刺联合中药为主要疗法,对照组505例(552只眼)采用西药或中药治疗。Meta分析结果表明,试验组在总有效率[OR=3.600,95%CI(2.550,5.080),Z=7.300,P=0.000]、平均视野缺损[MD=-2.940,95%CI(-4.190,-1.690),Z=4.600,P=0.000]、BCVA[MD=0.080,95%CI(0.040,0.110),Z=4.380,P=0.000]、平均视野敏感度[MD=2.070,95%CI(1.010,3.130),Z=3.830,P=0.000]、RNFL厚度[MD=12.380,95%CI(8.150,16.610),Z=5.730,P=0.000]方面均优于对照组。GRADE评价显示,总有效率为中级质量证据,RNFL、BCVA作为结局指标为低质量证据,视野指标(MS、MD)为极低质量证据。结论针刺联合中药治疗NAION较单纯西药、中药相比,能有效提升患者视力,扩大视野,是值得推广的联合疗法。
