目的分析输血次数与多次输血血液病患者输注效果的关系。方法选取2020年5月—2023年7月菏泽市立医院收治的600例多次输血(≥2次)的血液病患者作为研究对象,根据输血次数不同将患者分为A组225例(2~3次)、B组195例(4~6次)及C组180例(≥7次)。比较3组患者血小板抗体阳性率;比较血小板抗体阳性与阴性患者输注血小板后1、24 h校正血小板计数增加值(CCI)及输注有效率。结果600例患者中共226例患者检测血小板抗体阳性,阳性率为37.67%,其中C组血小板抗体阳性率高于A、B组(P<0.01)。血小板抗体阳性者输注后1、24 h CCI及输注有效率均低于血小板阴性患者(P<0.01)。结论输血次数越多,血液病患者血小板抗体阳性率越高,而血小板抗体阳性患者的血小板输注效果较差,而血小板抗体筛查能有效提高输血效果。
目的:本研究探讨大量输血(massive transfusion, MT)对创伤患者炎症标志物、血清电解质、凝血及免疫功能的影响。方法:研究纳入我院急诊科收治的136例创伤患者,分为MT组(41例)和一般输血组(对照组95例)。比较两组患者输血前后各指标变化情况,包括炎症标志物:白细胞介素-6 (IL-6)、白细胞介素-8 (IL-8)、粒细胞集落刺激因子(G-CSF)、单核细胞趋化蛋白-1 (MCP-1)、中性粒细胞与淋巴细胞比值(NLR)和血小板与淋巴细胞比值(PLR);电解质:K+、Na+、Cl−、Ca2+和TCO2;凝血指标:PT、APTT、TT、FIB和PLT;免疫指标:CD3+ T、CD4+ T和CD4+/CD8+。结果:输血后,MT组IL-6、IL-8和MCP-1显著高于对照组(P 0.05)。电解质方面,MT组K+、Ca2+和TCO2浓度明显降低(P +数值两组均升高且MT组更显著(P −水平无统计学差异(P > 0.05)。凝血功能上,MT组PLT、FIB数值降低,PT、APTT、TT时间延长(P + T、CD4+ T和CD4+/CD8+显著降低(P Objective: This study investigates the impact of massive transfusion (MT) on inflammatory markers, serum electrolytes, coagulation, and immune function in trauma patients. Methods: A total of 136 trauma patients admitted to the emergency department of our hospital were enrolled and divided into the MT group (41 cases) and the general transfusion group (control group, 95 cases). The changes in various indicators before and after transfusion were compared between the two groups, including inflammatory markers: interleukin-6 (IL-6), interleukin-8 (IL-8), granulocyte colony-stimulating factor (G-CSF), monocyte chemoattractant protein-1 (MCP-1), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR);electrolytes: K+, Na+, Cl−, Ca2+, and TCO2;coagulation parameters: PT, APTT, TT, FIB, and PLT;and immune parameters: CD3+ T, CD4+ T, and CD4+/CD8+. Results: After transfusion, the MT group showed significantly higher levels of IL-6, IL-8, and MCP-1 compared to the control group (P 0.05). In terms of electrolytes, the MT group ex
