Asymmetric organocatalysts has been increasingly recognized as an important green alternative the highly-developed asymmetric transition metal catalysis and biotransformation. However, organocatalysis is just in its infancy and has many limitations such low efficiency and limited substrate scopes. We presented herein a novel strategy to address the above challenges by incorporating ionic-liquid moieties as building blocks for organocatalysts. The chiral ionic-liquid (CIL) organocatalysts still maintained the unique properties of ionic liquid, and meanwhile, served as efficient catalyst for judiciously selected reactions. The CIL organocatalysts were shown to be highly efficient and stereoselective catalysts for asymmetric Michael additions. By simple swap of the ionic liquid anion with a surfactant anion, a highly efficient catalysis was realized for the first time in pure water.
由于不需要复杂的样品前处理过程,并具有实时、原位分析等特点,常压敞开式离子化技术成为近年来质谱研究的热点之一.实时直接分析(direct analysis in real time,DART)是近年来出现的一种常压敞开式离子化新技术,在食品安全、环境监测、爆炸物检测以及生物医药等诸多研究领域均有广泛的应用.本文简单介绍了常压敞开式离子化方法的发展,DART的基本原理和研究现状.进而介绍了我国质谱研究人员在基于DART的质谱仪器改进、联用技术以及生物药物等检测分析方面取得的新进展和新成果.
