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国家自然科学基金(30572176)

作品数:13 被引量:9H指数:2
相关作者:方琦陈忠诸葛正兵金春雷更多>>
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发文基金:国家自然科学基金浙江省自然科学基金更多>>
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杏仁核电点燃癫痫对大鼠穿梭箱被动回避反应的记忆保持能力的作用被引量:5
2008年
目的:探讨杏仁核电点燃癫痫对大鼠穿梭箱被动回避反应的记忆保持能力的影响。方法:大鼠每24h进行一次电刺激直至完全点燃,然后利用穿梭箱系统检测慢性电点燃癫痫对大鼠被动回避反应的记忆保持能力的作用;另一组动物于训练前5min给予杏仁核电刺激诱发癫痫大发作,观察癫痫的急性发作对记忆保持能力的作用。结果:在被动回避反应训练过程以及测试第1天,慢性点燃癫痫组和对照组动物进入暗箱的反应潜时没有明显差异;在测试第5天,慢性点燃癫痫组动物进入暗箱的反应潜时比对照组动物明显增加。另外,癫痫的急性发作使大鼠在测试第1天和第5天进入暗箱的反应潜时明显缩短。结论:慢性杏仁核电点燃癫痫可使大鼠被动回避反应的记忆保持能力增加,而癫痫的急性发作减弱了大鼠的记忆保持能力。
诸葛正兵方琦金春雷陈忠
关键词:癫痫杏仁核
Unilateral low-frequency stimulation of central piriform cortex has inhibitory effect on amygdaloid-kindled seizures in rats
Aim: The piriform cortex (PC) is considered to be critically involved in the genesis of lirabic seizures. In t...
Zhu - Ge Zheng - Bing Zhu Yuan - Yuan Wu Deng - Chang Wang Shuang Chen Zhong Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058
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Protective effect of carnosine against NMDA-induced neurotoxicity in differentiated rat PC12 cells
Aim: To investigat the neuroprolective effects of carnosine and its mechanisms of action in an in vitro model ...
Shen Yao Fan Yan - Yin Fan Xiao - Ning Dai Hai - Bin, Fu Qiu - Li Hu Wei - Wei Hu Chen Zhong Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058
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ω-Conotoxin MVIIA inhibits amygdaloid kindled seizures in rats
Aim: to - Conotoxin MVIIA (ω - CTX MVIIA) is a reversible and potent antagonist of N - typed voltage - depende...
Wu Deng - Chang Wang Shuang Zhu Yuan - Yuan Chen Zhong Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058
关键词:CTX
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Protective effect of carnosine on amyloid - β42 - induced neurotoxicity in differentiated rat PC12 cells is independent of histamine pathway
2006年
Fu Qiu-Li Dai Hai-Bin Shen Yao Hu Wei-wei Chen Zhong
Low-frequency stimulation of histaminergic tuberomammillary nucleus facilitates basolateral amygdaloid kindling in rats
Aim: The tuberomammillaiy nucleus ( TM) , located in the posterior hypothalamus, is the sole seat of histamine...
Zhu - Ge Zheng - Bing Wu Deng - Chang Wang Shuang Jin Chun - Lei Chen Zhong Department of Pharmacology, School of Medicine, Zhejiang University Hangzhou 310058
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The role of carnosine-histidine-histamine pathway in the CNS
Epilepsy is one of the most common neurological disorders and characterized by recurrent seizures,afflicting a...
Yao SHEN,Wei-Wei HU,Chun-Lei JIN,Shi-Hong ZHANG,Zhong CHEN~* Department of Pharmacology,Institute of Neuroscience,School of Medicine,Zhejiang University,Hangzhou 310058, China
关键词:HISTAMINE
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组胺对NMDA诱发的神经元兴奋性损伤的保护作用及其机制
目的在细胞水平探讨组胺及其受体在NMDA诱发的神经元损伤中的作用及其机制。方法采用原代新生大鼠皮层细胞培养的方法,以NMDA急性损伤为模型,观察组胺及H3受体拈抗剂对神经元的作用及机制。结果 NMDA100mM作用3小时...
戴海斌沈耀胡薇薇范彦英陈忠
关键词:组胺CLOBENPROPITNMDA神经元
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Unilateral low -frequency stimulation of central piriform cortex has inhibitory effect on amygdaloid- kindled seizures in rats
2006年
Zhu - Ge Zheng - Bing Zhu Yuan - Yuan Wu Deng - Chang Wang Shuang Chen Zhong
关键词:四肢抽搐
Low frequency stimulation of fastigial nucleus delays amygdaloid kindling seizures in rats
2006年
Wang ShuangWu Deng - ChangZhu - Ge Zheng - BingZhu Yuan- YuanChen Zhong
关键词:耐药性癫痫
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