Dear Editor, Eukaryotic transcriptional regulation networks are extremely complex. Usually, multiple transcription factors (TFs) bind to the promoter region of a gene and cooperate to control gene expression precisely. Identifying cooperative TFs remains a major challenge in modem biological research. Various types of data, including genomic sequences, expression profiles, ChiP-chip data and protein-protein interactions, have been used to identify mechanisms of cooperative transcriptional regulation.
