Iridium-catalyzed allylic substitutions often occur to generate chiral,branched products and complement the ub...
Wenbo Liu,Lixin Dai and Shuli You* State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry Chinese Academy of Sciences,345 Lingling Lu,Shanghai 200032
Fluorinating organic molecule significantly improves many of their properties, including solubility,bioavailab...
Guosheng Liu,Tao Wu and Shuifa Qiu 1 State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences
The spiroindolenine and spiroindoline units are prevalent heterocyclic motifs of a large family of alkaloid na...
Qingfeng Wu,Shuli You~* State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry Chinese Academy of Sciences,345 Lingling Lu,Shanghai,200032 China
A new type of chiral bisoxazoline ligands 1 based on spiro[4,4]-1,6-nonadiene backbone was easily prepared in six steps from racemic spiro[4,4]-nonane-1,6-dione,with the Pd-catalyzed coupling of the enol triflates with CO and amino alcohols as the key steps for the construction of the oxazoline moiety. The structure of the ligand (R,S,S)-1b was unambiguously established by X-ray crystallographic analysis. The chiral Cu(II) complex generated in situ from the combination of spiro bisoxazoline ligand (S,S,S)-1c and Cu(OTf)2 was effective in the catalysis of asymmetric chlorination of the β-ketoester,methyl 1-oxo-2,3-dihydro-1H-indene-2-carboxylate,affording the corresponding chlorinated derivative in 99% yield with 17% ee.
