The active contour model based on local image fitting （LIF） energy is an effective method to deal with intensity inhomo- geneities, but it always conflicts with the local minimum problem because LIF has a nonconvex energy function form. At the same time, the parameters of LIF are hard to be chosen for better per- formance. A global minimization of the adaptive LIF energy model is proposed. The regularized length term which constrains the zero level set is introduced to improve the accuracy of the bound- aries, and a global minimization of the active contour model is presented, in addition, based on the statistical information of the intensity histogram, the standard deviation σ with respect to the truncated Gaussian window is automatically computed according to images. Consequently, the proposed method improves the performance and adaptivity to deal with the intensity inhomo- geneities. Experimental results for synthetic and real images show desirable performance and efficiency of the proposed method.
