Asymmetric epoxidation of α,β-unsaturated ketones has been extensively studied and several important procedures have been developed in the last decade. This review addresses the most significant advances in asymmetric epoxidation of α,β-unsaturated ketones using proline-derived α,α-diarylprolinols as catalysts. Special attention has been paid to the enantioselective epoxidation of chalcones, α,β-unsaturated trifluoromethyl, trichloromethyl ketones and β,γ-unsaturated α-keto esters based on the reseach of our group.
Considerable attention was given to the assembly 2-pyridone core structure for many years because these struct...
Xiaowei Wang~1,Gang Zhao~*,Shizheng Zhu~* Key Laboratory of Organofluorine Chemistry,Shanghai Institute of Organic Chemistry,The Chinese Academy of Sciences,345Lingling Road,Shanghai 200032,P.R.China
A novel and facile preparation of l,l-difluoroallyl substituted five-membered lactones or pyrrolidines in mod- erate yields through direct double electrophilic fluorination of 4,5-allenoic acids or tosylamides with SelectfluorTM F-TEAD-BF4 is described.
Trifluoromethyl-containing molecules are recognized as a useful class of compounds in drug discovery as well a...
Peng Li,Gang Zhao~*,Shizheng Zhu~* Key Laboratory of Organofluorine Chemistry,Shanghai Institute of Organic Chemistry,The Chinese Academy of Sciences,345Lingling Road,Shanghai 200032,P.R.China
