This study was designed to investigate the effects of α-synuclein on toxicity induced by long-term exposure to relatively low concentrations of rotenone.Compared with the control groups,the inhibition of cell viability which overexpressed α-synuclein(SH-SY5Y-Syn) improved after 1 and 2 weeks of rotenone treatment.The complex I activity was greater and the mitochondrial membrane swelling intensity was reduced after 1 and 2 weeks of treatment,which indicated that α-synuclein,at least in part,resists the rotenone-induced oxidative stress.The results indicate that α-synuclein has a dual effect on toxicity of rotenone according to exposure time in human SH-SY5Y cells.
LU LingLing,GU Li,LIANG Yuan,SUN XiaoHong,DUAN ChunLi & YANG Hui Beijing Institute for Neuroscience,Capital Medical University,The Beijing Center of Neural Regeneration and Repairingr,Key Laboratory for Neurodegenerative Disease of the Ministry of Education,Beijing 100069,China
